Oral Liquid Bottle Blister Packing | Leak-Proof Design

Bottle Type Application

Vial

Ampoule

Cartridge

Oral Liquid Bottle

Prefilled Syringe

Special-Shaped Bottle

Bottle type combination

Blister Packaging Solutions for Oral Liquid Bottle

From upright to oval-shaped bottles, our packaging system handles diverse liquid containers with leak-resistant precision. Complete with automatic feeding, capping support, and custom blister forming, it provides a seamless and efficient packaging process.

Select the Appropriate Blister Lines for Your Product

With 20 years' experience, we offer professional small-bottle blister packaging production lines, including for irregularly shaped bottles and multilingual leaflets,adapting fast to industry rules.

PBL-400SZ

High-speed Automatic Production Line for syringe/Ampoule/Vial/Oral Liquid/Cartridge

Punching frequency:
16-35 times / minute 1-12 plates / time
Boxing capacity:
200-350 boxes / min

Differences Between HIGHNOW Vial Blister Packaging Lines and Traditional Models

Traditional Mechanical Structure

Servo motor

Other brands

Material replacement by stopping the machine

Mechanical

Position each station manually after replacing the mould

One traction station

None

Mechanical type

14 to 15 pushers

No self-lubrication function

Cylinder control

Other brand bearings

Stainless steel

Motor

Control system

Replacement materials

Forming

Mold replacement and adjustment

Traction station

Feeder

Transfer station

Push device

Lubrication function

Carton automatic feeding device

Pneumatic components

Lid

HIGHNOW's Vial Blister Production Line Structure

+25 servo motors

SCADA network software: 1500 series PLC, Siemens touch screen

Production doesn't need to stop thanks to intelligent material switching.

Blisters are sturdy and full, positive pressure blowing, concave molding

Position each station manually after replacing the mould

Equipped with two traction stations and two servo motors

Vibration feeder with adjustable track

Using robots for quick and smooth operation

22 sets of pusher heads

Features a self-lubricating system

Servo control

Festo bearings, chains: German BKD brand

Hard anodized aluminum profiles

Your Trusted Partner for Vial Blister Packing

We work worldwide, delivering numerous benchmark projects across industries. Success is down to relentless pursuit of excellence in technology, quality, and service.

Saudi Arabia

Optimization plan for mold head debugging of Blister Lines for Vial Product

Russia

optimization plan of blister lines for ampoule product

Georgia

optimization plan of blister lines for ampoule+vial product

Indonesia

optimization plan of blister lines for syringe product

FAQ

Unlock Industry-Specific Packaging Solutions! Discover how HIGHNOW addresses unique challenges in pharmaceutical, pet food, food & cosmetics industries. From GMP compliance to moisture-proof barriers, our FAQs reveal specialized machines that boost efficiency 40%+, ensure zero contamination, and handle diverse materials. Click to explore tailored solutions for your industry!

What is the maximum production speed for oral liquid bottle blister packaging while ensuring zero leakage?

Our oral liquid bottle blister packaging line achieves ≥150 blisters per minute (equivalent to 300 bottles/minute in dual-line configuration) while maintaining leakage rate ≤0.003%. This performance is validated through 28-day continuous runs with parameters including: seal strength ≥35 N/25mm (ASTM F88), burst pressure ≥0.35 MPa, and vibration testing simulating transport conditions. All critical quality parameters demonstrate Cpk ≥1.67 across 10 million package validation.

How do you prevent liquid leakage through multi-point sealing technology for different bottle materials?

We implement 6-point precision sealing technology with independent temperature control (±0.8°C) per zone and pressure profiling from 0.4-0.9 MPa. The system accommodates PET, HDPE, and glass bottles (5-200ml) with material-specific parameter optimization. Validation data shows seal integrity ≥99.99% across materials, with accelerated aging studies confirming shelf life ≥24 months without seal degradation.

What methodology ensures perfect bottle orientation and prevents liquid spillage during high-speed transfer?

Our vision-guided robotic handling system achieves orientation accuracy ≥99.97% using 6-axis robots with ±0.4mm repeatability and adaptive grippers applying 2-30N controllable force. The system incorporates liquid detection sensors and anti-spill algorithms that automatically adjust acceleration profiles (limited to <1.8G) based on fill levels and viscosity (1-2000 cP).

How quickly can production change between different bottle sizes and formulations?

Our automated changeover system completes transitions in ≤8 minutes through recipe management storing 300+ configurations. The process includes: tooling replacement (3 minutes), parameter adjustment (2 minutes), system calibration (3 minutes). Validated ±0.3mm positioning accuracy across 500+ change cycles ensures immediate production readiness with zero product waste.

What is the total cost of ownership compared to traditional liquid packaging solutions?

Our TCO analysis demonstrates 40-45% lower costs over 7 years through: Energy efficiency (48% reduction via heat recovery), Material optimization (25% film savings), Labor reduction (60% via automation), and Quality improvement (70% reduction in leakage claims). Annual operating cost is €46,800 with ROI period of 14-16 months at European utility rates.

How do you prevent cross-contamination between different flavored oral liquids?

We implement flavor-segmentation protocols with validated CIP systems achieving 4-log reduction in flavor carryover. Features include: quick-disconnect components, flushed sealing surfaces, and residual monitoring showing <0.01 μg/cm² flavor transfer. Organoleptic testing confirms zero detectable flavor migration between production runs.

What sustainable packaging options are available while maintaining liquid product integrity?

We offer mono-material PP blister films (recyclable), bio-based polymers (40% renewable content), and lightweight designs reducing material usage by 30%. Validation confirms shelf life equivalence to conventional packaging with oxygen transmission rate <0.2 cc/m²/day and moisture barrier <0.3 g/m²/day, meeting ICH Q1A stability requirements.

How does the integrated inspection system detect leakers and packaging defects?

Our multi-sensor inspection system combines 5MP vision cameras (detecting seal defects ≥0.3mm), pressure decay testing (sensitivity 0.05 psi/min), and weight verification (±0.2g accuracy). The system achieves ≥99.98% defect detection with false rejection rate <0.005%, automatically diverting suspect packages for automated rework.

What regulatory documentation supports pediatric and geriatric oral liquid packaging?

We provide age-appropriate validation packages including: child-resistant testing per ISO 8317, senior-adult usability studies, dosing accuracy validation (±2% measured volume), and stability data for various storage conditions. Documentation supports global submissions with 21 CFR Part 11 compliant electronic records.

How do you ensure global support for continuous production of temperature-sensitive oral liquids?

Our global network maintains ≥99% spare parts availability with ≤12-hour emergency delivery. Services include: 24/7 remote monitoring, preventive maintenance programs, and temperature mapping validation for climate-sensitive products. Customer data shows ≥98.5% equipment uptime with ≤2-hour response time for critical issues affecting product stability.

From demand analysis to equipment delivery, we provide full-process service support:

24/7 online technical consultation, with a fault diagnosis rate of over 95%.

Provide on-site operation, maintenance, and GMP compliance training.

Global spare parts inventory network, rapid response within 72 hours.

Solutions for hardware and software upgrades based on production capacity requirements.

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Punching frequency:

Boxing capacity: